期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 27, 期 7, 页码 627-639出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2008.06.002
关键词
affinity-type bioassay; bioanalysis; biosensing; chemically-modified nanopore; chemical sensing; label-free single-molecule detection; nanopore sensing; resistive-pulse technique; solid-state nanopore; transport modulation
资金
- Hungarian Science Foundation [OTKA NF 69262]
- Hungarian Academy of Sciences
Sensing with chemically-modified nanopores is an emerging field that is expected to have major impact on bioanalysis and fundamental understanding of nanoscale chemical interactions down to the single-molecule level. The main strength of nanopore sensing is that it implies the prospect of label-free single-molecule detection by taking advantage of the built-in transport-modulation-based amplification mechanism. At present, fabrication and application of solid-state nanopores are becoming the focus of attention because, compared with their biological counterparts, they offer greater flexibility in terms of shape, size, and surface properties, as well as superior robustness. A breakthrough in label-free nanopore sensing for real-world applications is therefore expected from implementing solid-state nanopores, an area that is still developing. Without claiming comprehensiveness, the focus of this review comprises recent results and trends in nanopore-based sensing (i.e. emerging technologies for fabricating solid-state nanopores, their chemical functionalization, and detection methods for quantitative analysis). (C) 2008 Elsevier Ltd. All rights reserved.
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