期刊
TOXIN REVIEWS
卷 32, 期 2, 页码 19-33出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/15569543.2013.782504
关键词
Exposure; human health; metabolites; ochratoxin A; toxicity
类别
资金
- Czech Ministry of Health (IGA MZ CR)
- [NT 12051-3/2011]
Ochratoxin A (OTA) is a ubiquitous, naturally occurring chlorophenolic mycotoxin produced in contaminated food and feed by fungi of genera Penicillium and Aspergillus. OTA is a common contaminant of various foodstuffs of both plant and animal origin. OTA represents significant risk to human and animal health. OTA has been shown to be nephrotoxic, hepatotoxic, teratogenic, immunotoxic, neurotoxic, genotoxic and carcinogenic (possible human carcinogen-group 2B), being characterized by species and sex differences in sensitivity. In some aspects OTA remains as a controversial topic. Its metabolism, genotoxicity and mechanism of action for renal carcinogenicity have been discussed.
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