期刊
TOXICON
卷 153, 期 -, 页码 78-84出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2018.08.015
关键词
Fusarenon-X; Nivalenol; Toxicokinetic; Goat
资金
- Kasetsart Graduate Study Research Scholarship, the Graduate School, Kasetsart University, Bangkok, Thailand
The main aim of this research was to evaluate the toxicokinetic characteristics of fusarenon-X (FX) and its metabolite, nivalenol (NIV), in goats. The amounts of FX and NIV in post-mitochondrial (S-9), microsomal and cytosolic fractions of diverse tissues of the goat were also investigated. FX was intravenously (iv) or orally (po) administered to goats at dosages of 0.25 and 1 mg/kg bw, respectively. The concentrations of FX and NIV in plasma, feces and urine were quantified by liquid chromatography tandem-mass spectrometry (LC-ESI-MS/MS). The concentrations of FX in plasma were quantified up to 8 h with both routes of administration. A large amount of NIV (metabolite) was quantifiable in plasma, urine and feces after both administrations. The C-max value of FX was 413.39 +/- 206.84 ng/ml after po administration. The elimination half-life values were 1.64 +/- 0.32 h and 4.69 +/- 1.25 h after iv and po administration, respectively. In vitro experiments showed that the conversion FX-to-NIV mainly occurs in the liver microsomal fraction. This is the first study that evaluates the fate and metabolism of FX in ruminant species.
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