期刊
TOXICON
卷 61, 期 -, 页码 26-29出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2012.10.009
关键词
Intraperitoneal toxicity; Ebulin f; Ribosome-inactivating lectins; Small intestine; Apoptosis; TAC cells
资金
- Junta de Castilla y Leon [GR106]
- UVa-GIR
- Complutense University UCM-CAM research group [950247 MAT 2008-02542]
Dwarf elder fruits (Sambucus ebulus) contain the ribosome-inactivating lectin ebulin f structurally related to ricin. We investigated intraperitoneal toxicity of ebulin fin mice and found that it triggers specific derangement of the intestines. Ebulin f was much less toxic than ricin to mice when administered intraperitoneally. The targets were cells of the intestinal crypts, which underwent apoptosis. Small intestine crypts were more sensitive than large intestine crypts. (C) 2012 Elsevier Ltd. All rights reserved.
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