期刊
TOXICON
卷 60, 期 3, 页码 302-311出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2012.05.001
关键词
Snake venom; L-amino acid oxidase; Biological activities
资金
- Dalian Municipal Government Foundation for Natural Sciences [2008J22JH014]
- Liaoning BaiQianWang Talents Program [2008921069]
- Ministry of Education Science Research for Chinese returned overseas scholars [502277]
As one of the major protein (enzyme) components of snake venom (SV), L-amino acid oxidase (LAAO) plays an important role in the toxicities and biological activities for SV. Accumulated researches in the past decade gradually revealed that SV-LAAOs induce platelet aggregation, cell apoptosis and cytotoxicity, and have anti-microbial, anti-leishmaniasis, anti-tumor and anti-HIV activity. Except for the enzymatic and structural characteristics of SV-LAAOs, the biological functions of SV-LAAOs and relevant action mechanisms are also summarized and discussed in the review. This work might provide useful inputs for future studies on SV-LAAOs. (C) 2012 Elsevier Ltd. All rights reserved.
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