期刊
TOXICON
卷 58, 期 6-7, 页码 455-463出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2011.08.004
关键词
Muscarinic toxins; Muscarinic receptors; Three-finger fold toxins; GPCRs
Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, these toxins are invaluable tools for studying the physiological role, molecular functioning and structural organization of the five subtypes of these G-Protein Coupled Receptors. We review the data on the most relevant results dealing with the isolation/identification, mode of action, structure/function and exploitation of these toxins and finally highlight the unresolved issues related to their pharmacological studies. (C) 2011 Elsevier Ltd. All rights reserved.
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