期刊
TOXICON
卷 55, 期 7, 页码 1353-1357出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2010.02.009
关键词
Tetrodotoxin; 6-epi-tetrodotoxin; Newt; Notophthalmus viridescens; Organ distribution; Monoclonal antibody
资金
- Ministry of Education, Science and Culture of Japan JSPS [21380070]
- Grants-in-Aid for Scientific Research [21380070] Funding Source: KAKEN
High levels of tetrodotoxin (TTX) and of its analogue 6-epi-tetrodotoxin have been detected in skin and liver extracts of the red-spotted newt Notophthalmus viridescens assayed by a post-column fluorescent-HPLC system. Using a monoclonal antibody-based immunoenzymatic technique, TTX was localized in the granular glands of the epidermis as well as in the muscle layer between the muscle fibres, but also in most organs suggesting that TTX is stored in the whole body of the newt and is secreted by skin glands. (C) 2010 Elsevier Ltd. All rights reserved.
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