期刊
TOXICON
卷 56, 期 8, 页码 1381-1387出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2010.08.003
关键词
Palytoxin; Ovatoxin; Mascarenotoxin; LC/TOF/MS; Ostreopsis cf. ovata
资金
- Ministry of Health
- Regione Campania - Assessorato alla Sanita
- Italian Ministry of Environment
- Istituto Zooprofilattico Sperimentale del Mezzogiorno and Stazione Zoologica Anton Dohrn
A rapid, high resolution liquid chromatography coupled with ElectroSpray Ionization Time-Of-Flight Mass Spectrometry (ESI/TOF/MS) method was developed for the determination of the toxin pattern in cultured cells of Ostreopsis cf. ovata from the Mediterranean Sea. The samples were separated on a Phenomenex Luna 3 mu HILIC 200A (150 x 2.00 mm) and analyzed by LC/TOF/MS with electrospray ionization (ESI) interface in positive ion mode. The method developed here provides the capability for a fully automated analysis, which requires relatively easy sample preparation and gives clean and simple chromatograms. The method was successfully applied to the determination of ovatoxin-a, mascarenotoxin-a and four new palytoxins in O. cf. ovata. Another new palytoxin was detected in the standard material from Palythoa tuberculosa provided by Wako Chemicals. (C) 2010 Elsevier Ltd. All rights reserved.
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