期刊
TOXICON
卷 52, 期 8, 页码 954-956出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2008.10.005
关键词
Domoic acid; Isodomoic acids A, B and C; Toxicity in vivo
资金
- New Zealand Foundation for Research, Science and Technology [CAWX0201, CAWX0301]
Seafood in many parts of the world may become contaminated with high levels of domoic acid and domoic acid isomers, and such seafood has been shown to cause toxic effects in humans and in marine animals. Domoic acid itself has been held responsible for the observed effects, although the possible contribution of the isomers to toxicity has not been investigated. In the present study, the acute intraperitoneal toxicity of isodomoic acid C in mice was found to be lower than that of domoic acid. Furthermore, the severities of the behavioural changes induced by isodomoic acids A, B and C were all much lower than that of domoic acid itself, suggesting that these substances pose relatively little risk to human or animal health. (C) 2008 Elsevier Ltd. All rights reserved.
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