期刊
TOXICOLOGY MECHANISMS AND METHODS
卷 22, 期 4, 页码 268-276出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15376516.2011.647112
关键词
Single-wall carbon nanotubes; rat aortic endothelial cells; oxidation; reactive oxygen species; native SDS-PAGE; high-performance liquid chromatograph
类别
资金
- National 973 plan of China [2010CB933904]
- National Natural Science Foundation of China [20877102, 20907075]
Oxidative stress is a major factor contributing to endothelial cell damage. Single-wall carbon nanotubes (SWCNTs) have oxidative properties; however, the oxidative effects of SWCNTs on endothelial cells are not fully understood. In the present study, we investigated the effects of oxidative stress induced by SWCNTs on rat aortic endothelial cells (RAECs). Various markers of cellular damage were assessed, such as biochemical and ES immunity indexes, and DNA and protein damage. Our findings suggest that RAEC endured oxidative damage following SWCNT exposure. Specifically, after SWCNTs exposure, non-enzymatic antioxidant glutathione was activated prior to superoxide dismutase activation in order to defend against oxidative stress. Additionally, it was found that as SWCNT concentration increased, so did the stress protein, heme oxygenase-1 (HO-1), expression levels. These changes may induce RAEC damage, and result in many serious diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据