期刊
TOXICOLOGY LETTERS
卷 225, 期 2, 页码 285-293出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2013.12.020
关键词
42-Hydroxy-palytoxin; Skeletal muscle; Cytotoxicity; Calcium; Cell elasticity
类别
资金
- Project of the Italian Ministry of Education University and Research [PRIN2009JS5YX9 002]
- Finanziamento Accordo Quadro Mi. S. E. - ICE - CRUI Bando [16-06-2010]
Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTXlike compounds. So far, 42-OH-PLTX is one of the few congeners available, and the study of its toxicity represents an important step toward a better comprehension of the mechanism of action of this family of compounds. From this perspective, the aim of this work was to investigate the in vivo and in vitro effect of 42-OH-PLTX on skeletal muscle, one of the most sensitive targets for PLTXs. Our results demonstrate that 42-OH-PLTX causes damage at the skeletal muscle level with a cytotoxic potency similar to that of PLTX. 42-OH-PLTX induces cytotoxicity and cell swelling in a Na+-dependent manner similar to the parent compound. However, the limited Ca2+-dependence of the toxic insult induced by 42-OH-PLTX suggests a specific mechanism of action for this analog. Our results also suggest an impaired response to the physiological agonist acetylcholine and altered cell elasticity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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