期刊
TOXICOLOGY LETTERS
卷 207, 期 3, 页码 197-203出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2011.09.011
关键词
ZnO nanomaterials; Toxicity; Physicochemical characteristics; Reactive oxygen species
类别
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology [2009-0082712, 2010-0019989, 2011-0019173]
- Research Institute for Veterinary Science of Seoul National University
- National Research Foundation of Korea [2009-0082712] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We studied the toxicity of ZnO nanomaterials in terms of physicochemical characteristics and reactive oxygen species (ROS) properties. ZnO nanorods [synthesized at room temperature (ZnO-RT, length; 18.0 +/- 4.2 nm) and at 60 degrees C (ZnO-60, length; 80.5 +/- 6.8 nm)] were used to evaluate the potential toxicity upon growth velocity-related particle size. The cytotoxicity of ZnO-60 was higher than that of ZnO-RT. We observed that the toxicity of ZnO-RT and ZnO-60 was related with ROS formation by using antioxidant N-acetylcysteine and electron spin resonance. Also, we found that the source of toxicity was not related to Zn2+ ions released from ZnO in 24 h treatment. Our results indicate that toxicity of ZnO nanorods is caused by the amounts of ROS. Our study strongly suggests that size of nanomaterial is not the sole factor to be considered, thus, the development of appropriate criteria based on morphological/physicochemical characteristics as well as synthesis procedures is needed to evaluate the precise toxicity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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