期刊
TOXICOLOGY IN VITRO
卷 28, 期 6, 页码 1126-1135出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2014.05.005
关键词
Microglial cells; Lipopolysaccharide; Inflammation; Resveratrol; SOCS
类别
资金
- Dottorato di ricerca in Biomorfologia Applicata e Citometabolismo dei Farmaci, University of Bari, Italy
Brain damage or exposure to inflammatory agents provokes the activation of microglia and secretion of pro-inflammatory and neurotoxic mediators responsible for neuronal loss. Several lines of evidence show that resveratrol, a natural non-flavonoid polyphenol, may exert a neuroprotective action in neurodegenerative diseases. Suppressor of cytokine signaling (SOCS) proteins are a family of eight members expressed by immune cells and the central nervous system (CNS) cells, that regulate immune processes within the CNS, including microglia activation. We demonstrate that resveratrol had anti-inflammatory effects in murine N13 microglial cells stimulated with lipopolysaccharide (LPS), through up-regulating SOCS-1 expression. Interestingly, in SOCS-1-silenced cells resveratrol failed to play a protective role after LPS treatment. Our data demonstrate that resveratrol can impair microglia activation by activating a SOCS-1 mediated signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved.
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