期刊
TOXICOLOGY IN VITRO
卷 27, 期 7, 页码 2084-2093出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2013.08.004
关键词
2008 Olympic Games; PM2.5; Cytotoxicity; Cytokine/chemokine; Inflammation; Oxidative stress
类别
资金
- National Natural Science Foundation Committee of China [20637020]
- Chinese Ministry of Science and Technology [2008AA062503]
- Helmholtz Zentrum Munchen [FE-75031]
Beijing has implemented systematic air pollution control legislation to reduce particulate emissions and improve air quality during the 2008 Summer Olympics, but whether the toxicity of fine fraction of particles (PM2.5) would be changed remains unclear. In present study we compared in vitro biological responses of PM2.5 collected before and during the Olympics and tried to reveal possible correlations between its chemical components and toxicological mechanism(s). We measured cytotoxicity, cytokines/chemokines, and related gene expressions in murine alveolar macrophages, MH-S, after treated with 20 PM2.5 samples. Significant, dose-dependent effects on cell viability, cytokine/chemokine release and mRNA expressions were observed. The cytotoxicity caused at equal mass concentration of PM2.5 was notably reduced (p < 0.05) by control measures, and significant association was found for viability and elemental zinc in PM2.5. Endotoxin content in PM2.5 correlated with all of the eight detected cytokines/chemokines; elemental and organic carbon correlated with four; arsenic and chromium correlated with six and three, respectively; iron and barium showed associations with two; nickel, magnesium, potassium, and calcium showed associations with one. PM2.5 toxicity in Beijing was substantially dependent on its chemical components, and lowering the levels of specific components in PM2.5 during the 2008 Olympics resulted in reduced biological responses. (C) 2013 Elsevier Ltd. All rights reserved.
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