期刊
TOXICOLOGY IN VITRO
卷 25, 期 7, 页码 1376-1384出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2011.05.008
关键词
Casiopeinas; Copper chelates; ROS; Antineoplastic
类别
资金
- Conacyt [60085]
- PAPIIT [IN-227110]
Casiopeinas is the generic name of a group of coordination complexes with a central copper atom bound to organic ligands, designed to be an alternative to cancer therapy. Indeed, some of these compounds can reduce implanted tumors in mice. Casiopeinas were expressly designed to interact with the genetic material, so the aim of the present work is to determine if these compounds have genotoxic activity. The results indicate that casiopeinas produce DNA fragmentation and base oxidation and suggest that their mode of action is related to reactive oxygen species (ROS) generation after copper reduction. (C) 2011 Elsevier Ltd. All rights reserved.
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