期刊
PLOS GENETICS
卷 11, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005378
关键词
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资金
- Aarne Koskelo Foundation
- Aase and Ejner Danielsens Foundation
- Academy of Finland [40758, 41071, 77299, 102318, 104781, 117787, 117844, 118590, 120315, 121584, 123885, 124243, 124282, 126925, 129269, 129293, 129378, 130326, 134309, 134791, 136895, 139635, 211497, 263836, 263924, 1114194, 24300796]
- Agency for Health Care Policy Research [HS06516]
- Agency for Science, Technology and Research of Singapore (A*STAR)
- Ahokas Foundation
- ALF/LUA research grant in Gothenburg
- ALK-Abello A/S (Horsholm, Denmark)
- Timber Merchant Vilhelm Bangs Foundation
- MEKOS Laboratories Denmark
- Althingi (the Icelandic Parliament)
- American Heart Association (AHA) [13POST16500011]
- ANR (Agence Nationale de la 359 Recherche)
- Ark (NHMRC Enabling Facility)
- Arthritis Research UK [19542, 18030]
- AstraZeneca
- Augustinus Foundation
- Australian National Health and Medical Research Council (NHMRC) [241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485, 613672, 613601, 1011506]
- Australian Research Council (ARC) [DP0770096, DP1093502]
- Becket Foundation
- bi-national BMBF/ANR funded project CARDomics [01KU0908A]
- Biobanking and Biomolecular Resources Research Infrastructure (BBMRINL) [184.021.007, CP 32]
- Biocentrum Helsinki
- Boehringer Ingelheim Foundation
- British Heart Foundation [RG/10/12/28456, SP/04/ 002]
- Canadian Institutes for Health Reseaerch [FRCN-CCT-83028]
- Cancer Research UK [C490/A10124, C490/A10119]
- Center for Medical Systems Biology (CMSB
- NWO Genomics)
- Centers for Disease Control and Prevention and Association of Schools of Public Health [1734, S043, S3486]
- Centre of Excellence Baden-Wurttemberg Metabolic Disorders
- Chief Scientist Office of the Scottish Government
- Clinical Research Facility at Guys & St Thomas NHS Foundation Trust
- Contrat de Projets Etat-Region (CPER)
- Croatian Science Council [8875]
- CVON (GENIUS)
- Danish Agency for Science, Technology and Innovation
- Danish Centre for Health Technology Assessment, Novo Nordisk Inc.
- Danish Council for Independent Research [DFF 1333-00124]
- Danish Diabetes Association
- Danish Heart Foundation
- Danish Medical Research Council
- Danish Ministry of Internal Affairs and Health
- Danish National Research Foundation
- Danish Pharmaceutical Association
- Danish Pharmacists Fund
- Danish Research Council
- Deutsche Forschungsgemeinschaft
- Diabetes Hilfs-und Forschungsfonds Deutschland (DHFD)
- Dr. Robert Pfleger-Stiftung
- Dresden University of Technology Funding Grant, Med Drive
- Dutch Brain Foundation
- Dutch Diabetes Research Foundation
- Dutch Economic Structure Enhancing Fund (FES)
- Dutch Kidney Foundation
- Dutch Ministry for Health, Welfare and Sports
- Dutch Ministry of Economic Affairs
- Dutch Ministry of Education, Culture and Science
- Egmont Foundation
- Else Kraner-Fresenius Stiftung [2012_A147, P48/08//A11/08]
- Emil Aaltonen Foundation
- Erasmus Medical Center and Erasmus University, Rotterdam
- Estonian Ministry of Science and Education [SF0180142s08]
- European Commission [223004, 2004310, DGXII, FP6-EUROSPAN, FP6-EXGENESIS, FP6-LSHG-CT2006-018947, FP6-LSHG-CT-2006-01947, FP6-LSHM- CT-2004-503485, FP6-LSHM-CT-2006037593, FP6-LSHM-CT-2007-037273, FP7-201379, FP7-201668, FP7-279143, FP7-305739, FP7313010, FP7-ENGAGE-HEALTH-F4-2007-201413, FP7-EurHEALTHAgeing-277849, FP7-HEALTH-F42007-201550, HEALTH-2011.2.4.2-2-EU-MASCARA, HEALTH-F2-2008-201865-GEFOS, HEALTH-F7305507 HOMAGE, LSHM-CT-2006-037593, QLG1CT-2001-01252, QLG1-CT-2002-00896, QLG2-CT2002-01254]
- European Regional Development Fund (ERDF)
- Wissenschaftsoffensive TMO
- European Regional Development Fund to the Centre of Excellence in Genomics (EXCEGEN) [3.2.0304.11-0312]
- European Research Council (ERC) [2011-StG-280559-SEPI, 2011-294713-EPLORE, 230374]
- European Science Foundation (ESF) [EU/QLRT-2001-01254]
- EuroSTRESS project [FP-006]
- Finlands Slottery Machine Association
- Finnish Centre for Pensions (ETK)
- Finnish Cultural Foundation
- Finnish Diabetes Association
- Finnish Diabetes Research Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Foundation for Pediatric Research
- Finnish Funding Agency for Technology and Innovation [40058/07]
- Finnish Medical Society
- the Finnish Ministry of Education and Culture [627]
- Finnish Ministry of Health and Social Affairs [5254]
- Finnish National Public Health Institute (current National Institute for Health and Welfare)
- Finnish Special Governmental Subsidy for Health Sciences
- Finska Lakaresallskapet, Signe and Ane Gyllenberg Foundation
- Flemish League against Cancer, ITEA2 (project Care4Me)
- Folkhalsan Research Foundation
- Fonds voor Wetenschappelijk Onderzoek (FWO) Vlaanderen
- Foundation for Life and Health in Finland
- the Foundation for Strategic Research (SSF)
- Stockholm County Council [560283]
- G. Ph. Verhagen Foundation
- Gene-diet Interactions in Obesity' project (GENDINOB)
- Genetic Association Information Network (GAIN)
- GENEVA Coordinating Center [U01 HG 004446]
- GenomEUtwin [EU/QLRT2001-01254, QLG2-CT-2002-01254]
- German Bundesministerium fuer Forschung und Technology [01 AK 803 A-H, 01 IG 07015 G]
- German Diabetes Association
- German Ministry of Cultural Affairs
- German Federal Ministry of Education and Research (BMBF) [03IS2061A, 03ZIK012, 01ZZ9603, 01ZZ0103, 01ZZ0403]
- German National Genome Research Network (NGFN-2 and NGFN-plus)
- German Research Council [SFB1052]
- Great Wine Estates of the Margaret River region of Western Australia
- Greek General Secretary of Research and Technology research grant (PENED
- Gyllenberg Foundation
- Health Care Centers in Vasa, Narpes and Korsholm
- Health Fund of the Danish Health Insurance Societies
- the Helmholtz Zentrum Munchen-German Research Center for Environmental Health
- Helsinki University Central Hospital special government funds (EVO) [TYH7215, TKK2012005, TYH2012209]
- Hjartavernd (the Icelandic Heart Association)
- Ib Henriksen Foundation
- Illinois Department of Public Health
- Translational Genomics Research Institute
- INTERREG IV Oberrhein Program [A28]
- Interuniversity Cardiology Institute of the Netherlands (ICIN) [09.001]
- Italian Ministry of Health targeted project [ICS110.1/RF97.71]
- Italian National Centre of Research InterOmics [PB05_ SP3]
- John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health
- Johns Hopkins University Center for Inherited Disease Research (CIDR)
- Joint grant from Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- Juho Vainio Foundation
- Juselius Foundation (Helsinki, Finland)
- International (JDRF)
- KfH Stiftung Praventivmedizin e. V.
- Knut and Alice Wallenberg Foundation
- Kuopio University Hospital
- Leenaards Foundation
- Leiden University Medical Center
- Liv och Halsa
- Local Government Pensions Institution (KEVA)
- Lokaal Gezondheids Overleg (LOGO) Leuven and Hageland
- LudwigMaximilians- Universitat
- LMUinnovativ
- Lundberg Foundation
- March of Dimes Birth Defects Foundation
- Medical Research Council [G0601966, G0700931, G0000934, G0500539, G0600705, G1002319, G0701863PrevMetSyn/SALVE, MC_ U106179471, MC_ UU_ 12019/1]
- MRC centre for Causal Analyses in Translational Epidemiology (MRC CAiTE)
- MRC Centre for Obesity and Related Metabolic Diseases
- MRC Human Genetics Unit
- Medical Research Council of Canada
- Mid-Atlantic Nutrition and Obesity Research Center [P30 DK072488]
- Ministry of the Flemish Community, Brussels, Belgium [G. 0881.13, G. 0880.13]
- MIUR-CNR Italian Flagship Project
- Montreal Heart Institute Foundation
- Munich Center of Health Sciences (MC Health)
- Municipal Health Care Center and Hospital in Jakobstad
- Narpes Health Care Foundation
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- National Cancer Institute [CA047988]
- National Center for Advancing Translational Sciences [UL1TR000124]
- National Center for Research Resources [U54RR020278]
- National Heart, Lung and Blood Institute (NHLBI) [1RL1MH083268-01, 5R01HL087679-02, HHSN268200800007C, HHSN268201200036C, HL043851, HL080467, HL087647, HL36310, HL45670, N01HC25195, N01HC55015, N01HC55016, N01HC55018, N01HC55019, N01HC55020, N01HC55021, N01HC55022, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, N02HL64278, R01HL086694, R01HL087641, R01HL087652, R01HL087676, R01HL59367, R01HL103612, R01HL105756, R01HL120393, U01HL080295]
- National Human Genome Research Institute (NHGRI) [U01HG004402]
- National Institute of Child Health and Human Development (NICHD)
- National Institute of Diabetes and Digestive and Kidney Disease (NIDDKDRC) [P30 DK072488, 1R01DK8925601, DK063491, R01DK089256]
- National Institute of Food and Agriculture [2007-35205-17883]
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA) [263-MA-410953, 263-MD-821336, 263-MD-9164, AG023629, AG13196, NO1AG12109, P30AG10161, R01AG15819, R01AG17917, R01AG023629, R01AG30146]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [5-P60-AR30701, 5-P60-AR49465-03]
- National Institutes of Health (NIH) [1R01DK8925601, 1RC2MH089951, 1RC2MH089995, 1Z01HG000024, 2T32 HL 00705536, 5R01DK075681, 5R01MH63706: 02, AA014041, AA07535, AA10248, AA13320, AA13321, AA13326, AG028555, AG08724, AG04563, AG10175, AG08861, DA12854, DK046200, DK091718, F32AR059469, HG002651, HHSN268200625226C, HHSN268200782096C, HL084729, MH081802, N01AG12100, N01HG65403, R01AG011101, R01AG030146, R01D0042157-01A, R01DK062370, R01DK072193, R01DK093757, R01DK075787, R01HL71981, R01MH59565, R01MH59566, R01MH59571, R01MH59586, R01MH59587, R01MH59588, R01MH60870, R01MH60879, R01MH61675, R01MH67257, R01MH81800, R01NS45012, U01066134, U01CA098233, U01DK062418, U01HG004423, U01HG004436, U01HG004438, U01HL072515-06, U01HL105198, U01HL84756, U01MH79469, U01MH79470, U01NS069208-01, UL1RR025005]
- NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- NIHR Cambridge Biomedical research Centre
- the Netherlands Heart Foundation [2001 D 032]
- Netherlands Organisation for Scientific Research (NWO
- Geestkracht program grant) [10-000-1002, 050-060-810, 100-001-004, 175.010.2003.005, 175.010.2005.011, 175.010.2007.006, 261-98-710, 40-0056-98-9032, 400-05-717, 452-04-314, 452-06-004, 480-01-006, 480-04-004, 480-05-003, 480-07-001, 481-08-013, 60-60600-97-118, 904-61-090, 904-61-193, 911-03012, 985-10-002, Addiction-31160008, GB-MW 94038- 011, SPI 56-464-14192]
- Netherlands Organization for the Health Research and Development (ZonMw) [91111025]
- Nordic Center of Excellence in Disease Genetics
- Nordic Centre of Excellence on Systems biology in controlled dietary interventions and cohort studies, SYSDIET [070014]
- Northern Netherlands Collaboration of Provinces (SNN)
- Novo Nordisk Foundation
- Office of Research and Development, Medical Research Service
- Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs
- Ollqvist Foundation
- Paavo Nurmi Foundation
- Pahlssons Foundation
- Paivikki and Sakari Sohlberg Foundation
- Perklen Foundation
- Republic of Croatia Ministry of Science, Education and Sports research [108-1080315-0302]
- Research Centre for Prevention and Health
- Capital Region of Denmark
- Research Foundation of Copenhagen County
- Research Institute for Diseases in the Elderly [014-93-015]
- Reynold's Foundation
- Rotterdam Oncologic Thoracic Study Group, Erasmus Trust Fund, Foundation against Cancer
- Royal Swedish Academy of Science
- Russian Foundation for Basic Research [NWO-RFBR 047.017.043]
- Rutgers University Cell and DNA Repository cooperative agreement [NIMH U24 MH068457-06]
- Samfundet Folkhalsan
- Sigrid Juselius Foundation
- Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds [9M048, 9N035]
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Societe Francophone du 358 Diabste (SFD)
- South Tyrolean Sparkasse Foundation
- Stichting Nationale Computerfaciliteiten (National Computing Facilities Foundation, NCF)
- Strategic Cardiovascular Programme of Karolinska Institutet
- Susan G. Komen Breast Cancer Foundation
- Swedish Cancer Society
- Swedish Cultural Foundation in Finland
- Swedish Diabetes Association
- Swedish Diabetes Foundation [2013-024]
- Swedish Foundation for Strategic Research (SSF) [ICA08-0047]
- Swedish HeartLung Foundation [20120197]
- Swedish Medical Research Council [K2007-66X-20270-01-3, 20121397]
- Swedish Ministry for Higher Education
- Swedish Research Council [8691, M-2005-1112, 2009-2298]
- Swedish Society for Medical Research
- Swiss National Science Foundation [31003A-143914, 3200B0105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468, 33CS30148401]
- SystemsX.ch [51RTP0_151019]
- Tampere Tuberculosis Foundation
- TEKES [40058/07, 70103/06]
- The Paul Michael Donovan Charitable Foundation
- Torsten and Ragnar Sderberg Foundation
- Umea Medical Research Foundation
- United Kingdom NIHR Cambridge Biomedical Research Centre
- Universities and Research of the Autonomous Province of Bolzano, South Tyrol
- University Hospital of Regensburg (ReForM A, ReForM C)
- University Hospital Oulu, Biocenter, University of Oulu, Finland [75617]
- University Medical Center Groningen
- University of Groningen
- University of Maryland General Clinical Research Center [M01RR16500, AG000219]
- University of Tartu (SP1GVARENG)
- University of Tromso, Norwegian Research Council [185764]
- Vasterbottens Intervention Programme
- Velux Foundation
- VU University Institute for Health and Care Research (EMGO+)
- Neuroscience Campus Amsterdam (NCA)
- Wellcome Trust [064890, 068545/Z/02, 076113/B/04/Z, 077016/Z/05/Z, 079895, 084723/Z/08/Z, 086596/Z/08/Z, 088869/B/09/Z, 089062, 090532, 098017, 098051, 098381]
- Western Australian DNA Bank (NHMRC Enabling Facility)
- Yrjo Jahnsson Foundation [56358]
- Zorg Onderzoek Nederland-Medische Wetenschappen, KWF Kankerbestrijding, Stichting Centraal Fonds Reserves van voormalig Vrijwillige Ziekenfondsverzekeringen
- National Institute for Health and Welfare (THL)
- National Institute for Health Research (NIHR) [RP-PG-0407-10371]
- National Institute of Allergy and Infectious Diseases (NIAID)
- Swedish Foundation for Strategic Research (SSF) [ICA08-0047] Funding Source: Swedish Foundation for Strategic Research (SSF)
- MRC [G0601966, MC_UU_12015/5, MC_UU_12015/1, G0700931, G1002319, G0000934, MR/N01104X/1, G0600705, MC_UU_12019/1, MC_UU_12015/2, MR/K002414/1, MC_PC_U127561128, MR/K013351/1, MC_UP_A100_1003, G1001799, MC_U106179472] Funding Source: UKRI
- Wellcome Trust [088869/B/09/Z] Funding Source: Wellcome Trust
- British Heart Foundation [RG/13/2/30098, RG/10/12/28456] Funding Source: researchfish
- Cancer Research UK [14136] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710] Funding Source: researchfish
- Lundbeck Foundation [R190-2014-3904] Funding Source: researchfish
- Medical Research Council [G0600705, MC_UU_12015/1, MC_UU_12015/2, G1000143, MC_PC_U127561128, MC_UU_12019/1, MR/K013351/1, G1001799, MC_U106179471, MR/N01104X/1, MC_UP_A100_1003, G0000934, MR/K002414/1, G1002319, G0601966, G0401527, MC_U106179472, MC_UU_12015/5, G0700931] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0611-10099, NF-SI-0611-10219, NF-SI-0512-10135] Funding Source: researchfish
- NNF Center for Basic Metabolic Research [Pers Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC1016167, NNF13OC0005785, NNF13OC0005781, NNF14OC0011039, NNF11OC1014855, NNF14OC0009883, NNF13OC0004839, NNF14OC0010513, NNF12OC1016374] Funding Source: researchfish
- Versus Arthritis [20308] Funding Source: researchfish
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men <= 50y, men > 50y, women <= 50y, women > 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR< 5%) age-specific effects, of which 11 had larger effects in younger (< 50y) than in older adults (>= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
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