期刊
TOXICOLOGY IN VITRO
卷 22, 期 7, 页码 1742-1748出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2008.07.013
关键词
Salicornia herbacea; Isorhamnetin 3-O-beta-D-glucoside; Quercetin 3-O-beta-D-glucoside; MMP-9; MMP-2; AP-1
类别
资金
- Ministry of Land, Transport and Maritime Affairs, Republic of Korea [M2007-03]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [B10400107A280000100] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Ministry of Knowledge Economy (MKE), Republic of Korea [B0008892] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [핵06B3013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Flavonoid glycosides, isorhamnetin 3-0-11-D-glucoside, and quercetin 3-O-beta-D-glucoside were isolated from Salicornia herbacea and their inhibitory effects on matrix metalloproteinase-9 and -2 (MMP-9 and -2) were evaluated in human fibrosarcoma cell line (HT1080). In zymography experiments, these flavonoid glycosides led to the reduction of the expression levels and activities of MMP-9 and -2 without any significant difference between these flavonoid glycosides. Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides. Moreover, a transfection study carried out with AP-1 reporter construct revealed that the reporter activity was suppressed by treatment with isorhamnetin 3-O-beta-D-glucoside. Therefore, these results suggested that these flavonoid glycosides have a potential as valuable natural chemopreventive agents for cancer. (C) 2008 Elsevier Ltd. All rights reserved.
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