期刊
TOXICOLOGY AND INDUSTRIAL HEALTH
卷 32, 期 6, 页码 1064-1073出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748233714545502
关键词
Physalis peruviana L.; carbon tetrachloride; oxidative stress; reproductive toxicity
Treatment of rats with carbon tetrachloride (CCI4; 2 ml/kg body weight) once a week for I 2 weeks caused a significant decrease in serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone. These decreases in sex hormones were reduced with Physalis peruviana L. (Cape gooseberry) juice supplementation. In addition, testicular activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase suppressed with CCI4 were elevated after P. peruviana juice supplements. P. peruviana juice supplementation significantly increased the testicular glutathione and significantly decreased the level of lipid peroxidation and the nitric oxide production compared with the CCI4 group. In addition, the decline in the activity of antioxidant enzymes after CCI4 was ameliorated by P. peruviana. Moreover, degeneration of germ and Leydig cells along with deformities in spermatogenesis induced after CCI4 injections were prevented with the supplementation of P. peruviana juice. Furthermore, P. peruviana juice attenuated CCI4-induced apoptosis in testes tissue by inhibition of caspase-3 activity. The results clearly demonstrate that P. peruviana juice augments the antioxidants defense mechanism against CCI4-induced reproductive toxicity and provides evidence that the juice may have a therapeutic role in free radical-mediated diseases and infertility.
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