期刊
TOXICOLOGY AND INDUSTRIAL HEALTH
卷 31, 期 9, 页码 792-801出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748233713475509
关键词
Allium cepa; DNA content; genotoxic effect; interphase nuclear volume; magnesium diglutamate; monoammonium glutamate; monopotassium glutamate; monosodium glutamate
The effects of different treatments with flavour enhancers monosodium glutamate, monopotassium glutamate, calcium diglutamate, monoammonium glutamate, and magnesium diglutamate on the cytology, DNA content, and interphase nuclear volume (INV) of A. cepa were investigated. Three concentrations of these additives - 20, 40, and 60ppm - were applied for 6, 12, and 24h. All the concentrations of these chemicals showed an inhibitory effect on cell division in root tips of A. cepa and caused a decrease in mitotic index values. Additionally, all the treatments changed the frequency of mitotic phases when compared with the control groups. These compounds increased chromosome abnormalities, among them are micronuclei, c-mitosis, anaphase bridges, stickiness, binucleus, laggards, and breaks. The nuclear DNA content and INV decreased when compared with control groups.
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