期刊
TOXICOLOGY AND INDUSTRIAL HEALTH
卷 27, 期 7, 页码 599-605出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748233710394234
关键词
Cetraria islandica; antigenotoxicity; antioxidant enzymes
资金
- [P50031001-1]
In this study, the antigenotoxic and antioxidant effects of Cetraria islandica methanol (CME) extract were determined by using sister chromatid exchange (SCE), micronuclei (MN) assays and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against effects of aflatoxin B1 (AFB(1)) induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN and MDA level decreased, SOD and GPx activities increased when 5 mg/mL and 10 mu g/mL doses of CME were added to AFBi-treated cultures. Also, the present results indicate that CME has strong antioxidative and the antigenotoxicity mechanisms of CME are associated with its antioxidant nature.
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