期刊
PLOS GENETICS
卷 11, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005373
关键词
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资金
- Deutsche Forschungsgemeinschaft
- ERASMUS fellowship
- Gatsby Charitable Foundation
- European Research Council
- Netherlands Organization for Scientific Research (ERA-PG research grant NWO-PROSIG) [855.50.018]
- Welcome program
- European Regional Development Fund
- Polish National Science Centre [UMO-2011/03/D/NZ9/04059]
- Danish Research Council FTP [09-062964, 11-117019, 09-065066]
- Estonian Research Council [IUT2-21]
- European Regional Fund (Center of Excellence in Environmental Adaptation)
- Academy of Finland (ERA-PG) [129940]
- Academy of Finland (Centre of Excellence program) [213509, 129628, 271832]
- Biocentrum Helsinki
- University of Helsinki
- Academy of Finland [275632, 283139, 140187]
- Doctoral Programme in Plant Sciences in the Doctoral School in Environmental, Food and Biological sciences at the University of Helsinki
- Finnish Graduate School in Plant Biology
- REGPOT WULS-PLANT HEALTH [FP7-286093]
- Polish National Science Centre Maestro6 project [UMO-2014/14/A/NZ1/00218]
- Polish National Science Centre Sonata2 project [UMO-2011/03/D/NZ9/04059]
- BBSRC [BBS/E/T/000PR6193, BBS/E/T/000PR5885] Funding Source: UKRI
- Academy of Finland (AKA) [129940, 283139, 140187, 129940, 140187, 129628] Funding Source: Academy of Finland (AKA)
- Biotechnology and Biological Sciences Research Council [BBS/E/T/000PR5885, BBS/E/T/000PR6193] Funding Source: researchfish
Cysteine-rich receptor-like kinases (CRKs) are transmembrane proteins characterized by the presence of two domains of unknown function 26 (DUF26) in their ectodomain. The CRKs form one of the largest groups of receptor-like protein kinases in plants, but their biological functions have so far remained largely uncharacterized. We conducted a large-scale phenotyping approach of a nearly complete crk T-DNA insertion line collection showing that CRKs control important aspects of plant development and stress adaptation in response to biotic and abiotic stimuli in a non-redundant fashion. In particular, the analysis of reactive oxygen species (ROS)-related stress responses, such as regulation of the stomatal aperture, suggests that CRKs participate in ROS/redox signalling and sensing. CRKs play general and fine-tuning roles in the regulation of stomatal closure induced by microbial and abiotic cues. Despite their great number and high similarity, large-scale phenotyping identified specific functions in diverse processes for many CRKs and indicated that CRK2 and CRK5 play predominant roles in growth regulation and stress adaptation, respectively. As a whole, the CRKs contribute to specificity in ROS signalling. Individual CRKs control distinct responses in an antagonistic fashion suggesting future potential for using CRKs in genetic approaches to improve plant performance and stress tolerance.
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