期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 243, 期 1, 页码 87-95出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2009.11.016
关键词
Tribromophenol; Endocrine disruption; Sex hormones; Steroidogenic genes; Reproduction; Zebrafish
资金
- Ministry of Science and Technology of China [2006AA06Z420]
- National Nature Science Foundation of China [20890113]
- State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F-0; 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F-0-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F-1-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved
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