期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 244, 期 1, 页码 16-20出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2009.07.034
关键词
Oxidative stress; bZIP factor; Nrf1; Nrf2; Antioxidant
资金
- NCI NIH HHS [R01 CA091907, R01 CA091907-05] Funding Source: Medline
- NIDDK NIH HHS [K08 DK002603-01, R03 DK063757-01] Funding Source: Medline
Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The ability to mount an efficient response against the continuous threat posed by exogenous and endogenous oxidants is essential for cellular homeostasis and survival. Oxidative stress activates transcription of a variety of antioxidant genes through cis-acting sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family of transcription factors, including Nrf1 and Nrf2, that bind ARE have been identified. Nrf1 and Nrf2 are expressed in a wide range of tissues and cell types, and both bind the ARE as heterodimers with small Maf proteins. Numerous studies indicate a pivotal role of Nrf2 in ARE function. Herein, we review data derived from cell-based studies and knockout mice in an attempt to define the role and regulation of Nrf1 in oxidative stress response and other functions. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据