期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 248, 期 2, 页码 71-88出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2010.08.003
关键词
Head and neck tract cancer; Heavy metals; Tobacco; Professional exposure; Mechanisms; Carcinogenesis
Chronic exposures to heavy metals via tobacco smoking and professional exposure may increase the risk of head and neck cancer, although the epidemiologic evidence is limited by problems of low study power and inadequate adjustment for tobacco and professional exposure use. Numerous scientific reviews have examined the association of various heavy metals exposure with respiratory cancer as well as other cancer types, but few have been published on head and neck cancer. The purpose of this paper, therefore, is to review the head and neck tract cancer-related data on exposure to heavy metals via smoking and working exposure and to study the major mechanisms underlying some toxic metals carcinogenesis. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.
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