期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 244, 期 3, 页码 385-392出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2010.02.012
关键词
Arsenic trioxide; Transcription factor; Signal transduction; Reactive oxygen species
资金
- Uehara Memorial Foundation
- Sumitomo Foundation
- Grants-in-Aid for Scientific Research [22790137] Funding Source: KAKEN
Arsenic trioxide (As2O3) is widely used to treat acute promyelocytic leukemia (APL). Several lines of evidence have indicated that As2O3 affects signal transduction and transactivation of transcription factors, resulting in the stimulation of apoptosis in leukemia cells, because some transcription factors are reported to associate with the redox condition of the cells, and arsenicals cause oxidative stress. Thus, the disturbance and activation of the cellular signaling pathway and transcription factors due to reactive oxygen species (ROS) generation during arsenic exposure may explain the ability of As2O3 to induce a complete remission in relapsed APL patients. In this report, we review recent findings on ROS generation and alterations in signal transduction and in transactivation of transcription factors during As2O3 exposure in leukemia cells. (C) 2010 Elsevier Inc. All rights reserved.
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