期刊
TOXICOLOGICAL SCIENCES
卷 130, 期 2, 页码 217-228出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfs223
关键词
bioinformatics; toxicogenomics; liver; systems toxicology
类别
资金
- German Federal Ministry for Education and Research, Virtual Liver Network initiative [031 6154]
- ORISE Stipend of the FDA
Toxicogenomics enjoyed considerable attention as a ground-breaking addition to conventional toxicology assays at its inception. However, the pace at which toxicogenomics was expected to perform has been tempered in recent years. Next to cost, the lack of advanced knowledge discovery and data mining tools significantly hampered progress in this new field of toxicological sciences. Recently, two of the largest toxicogenomics databases were made freely available to the public. These comprehensive studies are expected to stimulate knowledge discovery and development of novel data mining tools, which are essential to advance this field. In this review, we provide a concise summary of each of these two databases with a brief discussion on the commonalities and differences between them. We place our emphasis on some key questions in toxicogenomics and how these questions can be appropriately addressed with the two databases. Finally, we provide a perspective on the future direction of toxicogenomics and how new technologies such as RNA-Seq may impact this field.
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