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Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
Marc-Emmanuel Dumas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Understanding mouse models of disease through metabolomics
Julian L. Griffin
CURRENT OPINION IN CHEMICAL BIOLOGY (2006)
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily - A randomized controlled trial
Paul B. Watkins et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption
Tomoyoshi Soga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: Novel induction of 5-oxoprolinosis
Nigel J. Waters et al.
JOURNAL OF PROTEOME RESEARCH (2006)
Flux balance analysis in the era of metabolomics
Jong Min Lee et al.
BRIEFINGS IN BIOINFORMATICS (2006)
Biomarkers of cardiovascular disease - Molecular basis and practical considerations
Ramachandran S. Vasan
CIRCULATION (2006)
Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics
S Kochhar et al.
ANALYTICAL BIOCHEMISTRY (2006)
Pharmaco-metabonomic phenotyping and personalized drug treatment
TA Clayton et al.
NATURE (2006)
Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles
BR Underwood et al.
BRAIN (2006)
Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy
TA Tsang et al.
JOURNAL OF PROTEOME RESEARCH (2006)
Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters
B Sitter et al.
NMR IN BIOMEDICINE (2006)
The gut microbiota and lipid metabolism: Implications for human health and coronary heart disease
F. Fava et al.
CURRENT MEDICINAL CHEMISTRY (2006)
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease
MR Pears et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
METLIN - A metabolite mass spectral database
CA Smith et al.
THERAPEUTIC DRUG MONITORING (2005)
Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma
KO Boernsen et al.
ANALYTICAL CHEMISTRY (2005)
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
JC Lindon et al.
PHARMACOGENOMICS (2005)
Metabonomic identification of two distinct phenotypes in sprague-dawley (Crl:CD(SD)) rats
LC Robosky et al.
TOXICOLOGICAL SCIENCES (2005)
Expanding the use of magnetic resonance in the assessment of tumor response to therapy: Workshop report
J Evelhoch et al.
CANCER RESEARCH (2005)
Arginine deprivation and metabolomics: Important aspects of intermediary metabolism in relation to the differential sensitivity of normal and tumour cells
DN Wheatley
SEMINARS IN CANCER BIOLOGY (2005)
Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study
D Poli et al.
RESPIRATORY RESEARCH (2005)
The metabonomics of aging and development in the rat:: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS
RE Williams et al.
MOLECULAR BIOSYSTEMS (2005)
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
ME Bollard et al.
NMR IN BIOMEDICINE (2005)
Gut microorganisms, mammalian metabolism and personalized health care
JK Nicholson et al.
NATURE REVIEWS MICROBIOLOGY (2005)
GMD@CSB.DB:: the Golm Metabolome Database
J Kopka et al.
BIOINFORMATICS (2005)
Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats
H Wong et al.
TOXICOLOGICAL SCIENCES (2005)
The Orbitrap: a new mass spectrometer
QZ Hu et al.
JOURNAL OF MASS SPECTROMETRY (2005)
High resolution Ultra performance liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
ID Wilson et al.
JOURNAL OF PROTEOME RESEARCH (2005)
Discovery and development of biomarkers of neurological disease
T Dunckley et al.
DRUG DISCOVERY TODAY (2005)
Metabolomics applications of FT-ICR mass spectrometry
SC Brown et al.
MASS SPECTROMETRY REVIEWS (2005)
Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics
K Odunsi et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Mass spectrometry in metabolome analysis
SG Villas-Boas et al.
MASS SPECTROMETRY REVIEWS (2005)
Hepatic findings in long-term clinical trials of ximelagatran
WM Lee et al.
DRUG SAFETY (2005)
Metabolomics by numbers: acquiring and understanding global metabolite data
R Goodacre et al.
TRENDS IN BIOTECHNOLOGY (2004)
Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers
TG Kleno et al.
BIOMARKERS (2004)
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
J An et al.
NATURE MEDICINE (2004)
Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3
JL Griffin et al.
PHYSIOLOGICAL GENOMICS (2004)
Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity
RJ Mortishire-Smith et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice
M Mayr et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Metabonomics, dietary influences and cultural differences:: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects
EM Lenz et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2004)
Metabolic profiles to define the genome: can we hear the phenotypes?
JL Griffin
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES (2004)
Automatic alignment of individual peaks in large high-resolution spectral data sets
R Stoyanova et al.
JOURNAL OF MAGNETIC RESONANCE (2004)
Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
JK Nicholson et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Contemporary issues in toxicology - The role of metabonomics in toxicology and its evaluation by the COMET project
JC Lindon et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences
R Plumb et al.
ANALYST (2003)
In vivo toxicity screening programs using metabonomics
LC Robosky et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2002)
Analytical reproducibility in 1H NMR-based metabonomic urinalysis
HC Keun et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies
HC Keun et al.
ANALYTICAL CHEMISTRY (2002)
Metabolomics - the link between genotypes and phenotypes
O Fiehn
PLANT MOLECULAR BIOLOGY (2002)
Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra
E Holmes et al.
ANALYST (2002)
Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution 1H NMR spectroscopy of urine and pattern recognition
ME Bollard et al.
ANALYTICAL BIOCHEMISTRY (2001)
Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks
O Fiehn
COMPARATIVE AND FUNCTIONAL GENOMICS (2001)
Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T
LL Cheng et al.
FEBS LETTERS (2001)
Integrated studies on plant biology using multiparallel techniques
O Fiehn et al.
CURRENT OPINION IN BIOTECHNOLOGY (2001)
An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences:: application to the C57BL10J and Alpk:ApfCD mouse
CL Gavaghan et al.
FEBS LETTERS (2000)
Metabonomics:: Evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants
DG Robertson et al.
TOXICOLOGICAL SCIENCES (2000)