期刊
TOXICOLOGICAL SCIENCES
卷 112, 期 2, 页码 276-296出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfp188
关键词
ecotoxicology; toxicology; environmental fate; regulatory policy; risk assessment; nanoparticles
类别
资金
- Genome Canada through the Ontario Genomics Institute [2004-OGI-3-15]
- Genome Canada through the Ontario Genomics Institute
- Ontario Research Fund
- Bill and Melinda Gates Foundation
Quantum dots (QDs), an important class of emerging nanomaterial, are widely anticipated to find application in many consumer and clinical products in the near future. Premarket regulatory scrutiny is, thus, an issue gaining considerable attention. Previous review papers have focused primarily on the toxicity of QDs. From the point of view of product regulation, however, parameters that determine exposure (e.g., dosage, transformation, transportation, and persistence) are just as important as inherent toxicity. We have structured our review paper according to regulatory risk assessment practices, in order to improve the utility of existing knowledge in a regulatory context. Herein, we summarize the state of academic knowledge on QDs pertaining not only to toxicity, but also their physicochemical properties, and their biological and environmental fate. We conclude this review with recommendations on how to tailor future research efforts to address the specific needs of regulators.
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