期刊
TOXICOLOGIC PATHOLOGY
卷 41, 期 1, 页码 48-62出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623312452490
关键词
Asian sand dust; chronic toxicity; desertification; granuloma; lung; pulmonary lymph node
资金
- Global COE Program (Global Center of Excellence for Dryland Science), MEXT, Japan
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [24580425] Funding Source: KAKEN
Asian sand dust (ASD) events are associated with an increase in pulmonary morbidity and mortality. The number of ASD events has increased rapidly in the east Asian region since 2000. To study the chronic lung toxicity of ASD, saline suspensions of low doses (200 and 400 mu g) and high doses (800 and 3,000 mu g) of ASD were intratracheally instilled into ICR mice. Animals were sacrificed at 24 hr, 1 week, or 1, 2, or 3 months after instillation. Histopathological examination revealed that ASD induced acute inflammation at 24 hr after instillation. The acute inflammation was transient and subsided at 1 week and 1 month after instillation. At 2 and 3 months after instillation, focal infiltration of lymphocytes with accumulation of epithelioid macrophages, which is a suggestive finding of transformation to granuloma, and granuloma formation were occasionally observed. Aggregation of macrophages containing particles was observed in the pulmonary lymph nodes at 3 months after instillation in high-dose groups. Prolonged inflammatory foci (granuloma) and presence of ASD particles in pulmonary lymph nodes would have a chance to induce immunological modulation leading to adverse health effects in the exposed animals.
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