期刊
TOXICOLOGIC PATHOLOGY
卷 38, 期 1, 页码 198-202出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623309352003
关键词
fear conditioning; water maze; hippocampus; mice; irradiation; oxidative stress; neurogenesis
资金
- Alzheimer's Association [IIRG-05-14021]
- NASA [NNJ05HE63G]
This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events. including alterations in neurogenesis mid increased oxidative stress following irradiation and potential alterations m synaptic and dendritic markers.
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