期刊
TOXICOLOGIC PATHOLOGY
卷 38, 期 1, 页码 110-122出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623309354108
关键词
estrogen; BPA; BBP; cell transformation; breast cancer; epigenetic changes; neuregulin
资金
- NIH, USA, [R21 ES015894, U01 ES/CA 12771]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R21ES015894, U01ES012771] Funding Source: NIH RePORTER
There is growing concern that estrogenic environmental compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fueled by evidence indicating that natural estrogens, specifically 17 beta-estradiol, are important factors in the initiation and progression of breast cancer. We have developed an in vitro-in vivo model in which we have demonstrated the carcinogenicity of E2 in human breast epithelial cells MCF-10F. Hypermethylation of NRG1, STXBP6. BMP6, CSS3, SPRY1, and SNIP were found at different progression stages in this model. The use of this powerful and unique model has provided a tool for exploring whether bisphenol A and butyl benzyl phthalate have relevance in the initiation of breast cancer. These studies provide firsthand evidence that the natural estrogen 17 beta-estradiol and xenoestrogenic substances like bisphenol a are able to induce neoplastic transformation in human breast epithelial cells.
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