期刊
PLOS COMPUTATIONAL BIOLOGY
卷 11, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1004322
关键词
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资金
- Medical Research Council [MC-A022-5PB91, MC-A658-5TY30]
- National Institutes of Health [RO1 DA018341]
- National Science Foundation [PHYS-1066293]
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA018341] Funding Source: NIH RePORTER
- MRC [MC_UP_1102/6, MC_U105185857] Funding Source: UKRI
- Medical Research Council [MC_U105185857, MC_UP_1102/6] Funding Source: researchfish
- Wellcome Trust [103784/Z/14/Z] Funding Source: researchfish
Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions would provide a basis for a comprehensive understanding of locomotor behaviour. Here we introduce a discrete representation of behaviour in the nematode C. elegans. At each point in time, the worm's posture is approximated by its closest matching template from a set of 90 postures and locomotion is represented as sequences of postures. The frequency distribution of postural sequences is heavy-tailed with a core of frequent behaviours and a much larger set of rarely used behaviours. Responses to optogenetic and environmental stimuli can be quantified as changes in postural syntax: worms show different preferences for different sequences of postures drawn from the same set of templates. A discrete representation of behaviour will enable the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behaviour.
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