期刊
PLOS BIOLOGY
卷 13, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1002190
关键词
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资金
- Australian Research council DECRA fellowship [DE140101481]
- ARC Discovery Grant
- ARC Future Fellowship
- Australian Research Council [DE140101481] Funding Source: Australian Research Council
Observer bias and other experimenter effects occur when researchers' expectations influence study outcome. These biases are strongest when researchers expect a particular result, are measuring subjective variables, and have an incentive to produce data that confirm predictions. To minimize bias, it is good practice to work blind, meaning that experimenters are unaware of the identity or treatment group of their subjects while conducting research. Here, using text mining and a literature review, we find evidence that blind protocols are uncommon in the life sciences and that nonblind studies tend to report higher effect sizes and more significant p-values. We discuss methods to minimize bias and urge researchers, editors, and peer reviewers to keep blind protocols in mind.
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