期刊
PLOS BIOLOGY
卷 13, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1002125
关键词
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资金
- Cancer Research UK
- Lister Institute of Preventive Medicine
- Leducq Transatlantic Network Grant (Artemis)
- EMBO Young Investigator Program
- ERC [311719]
- BIRAX Regenerative Medicine Initiative
- EPSRC [EP/I017909/1, EP/I034602/1]
- UK Consortium on Mesoscale Engineering Sciences (UKCOMES) [EP/L00030X/1]
- EC [287703, 261507]
- Marie Curie Actions Fellowship of the FP7 People Program [255150]
- FCT [IF/00412/2012]
- HFSP Long-Term Fellowship
- Cancer Research UK [17351] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I034602/1, EP/L00030X/1, EP/I017909/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [15F14385] Funding Source: KAKEN
- EPSRC [EP/L00030X/1, EP/I017909/1, EP/I034602/1] Funding Source: UKRI
- European Research Council (ERC) [311719] Funding Source: European Research Council (ERC)
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments.
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