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Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac
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Exchange Protein Directly Activated by Cyclic AMP Isoform 2 Is Not a Direct Target of Sulfonylurea Drugs
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cAMP increases the sensitivity of exocytosis to Ca2+ primarily through protein kinase A in mouse pancreatic beta cells
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PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans
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Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
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The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
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Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog
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8-pCPT-2 '-O-Me-cAMP-AM: An improved Epac-selective cAMP analogue
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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by CAMP
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Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state
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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
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cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices
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KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATP
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Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac
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cAMP analog mapping of Epac1 and cAMP kinase - Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
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Structural basis for modulation and agonist specificity of HCN pacemaker channels
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Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic β-cells
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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
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Structure and regulation of the cAMP-binding domains of Epac2
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cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets
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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
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Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion
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cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic β-cells
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