期刊
TISSUE ENGINEERING PART B-REVIEWS
卷 20, 期 5, 页码 381-391出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2013.0530
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资金
- Bio and Medical Technology Development Program of the National Research Foundation (NRF) - Korean government (MEST) [2012M3A9B4028566]
- National Research Foundation of Korea [2012M3A9B4028566] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Tissue engineering for skeletal tissues including bone and cartilage have been focused on the use of adult stem cells. Although there are several pioneering researches on skeletal tissue regeneration from embryonic stem cells (ESCs), ethical issues and the possibility of immune rejection clouded further attention to the application of ESCs for nonlethal orthopedic conditions. However, the recent discovery of induced pluripotent stem cells (iPSCs) led to reconsider the use of these pluripotential cells for skeletal regeneration. The purpose of this review was to summarize the current knowledge of osteogenic and chondrogenic induction from ESCs and iPSCs and to provide a perspective on the application of iPSCs for skeletal regeneration.
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