期刊
TISSUE ENGINEERING PART A
卷 19, 期 3-4, 页码 529-537出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tea.2012.0208
关键词
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资金
- Nano-tech Foundation of Shanghai [1052nm0570045, 11nm0503100]
- National Natural Science Foundation of China [51003058, 81171477, 81271999]
- Shanghai Jiao Tong University [BXJ201235]
- Shanghai Key Laboratory of Orthopedics Implant
Physical barriers are commonly used to reduce peritendinous adhesion after injury. However, the inflammatory response to surgery cannot be prevented. This study was designed to evaluate the ability of ibuprofen-loaded poly(l-lactic acid)-polyethylene glycol (PELA) diblock copolymer fibrous membranes in preventing adhesion formation and reduce inflammation. Electrospun PELA fibrous membranes underwent mechanical testing and were characterized by morphology, surface wettability, drug release, and degradation. Results of an in vitro drug release study showed that a burst release was followed by sustained release from fibrous membranes with high initial ibuprofen content. Fewer L929 mouse fibroblasts adhered to and proliferated on the ibuprofen-loaded PELA fibrous membrane compared with tissue culture plates or PELA fibrous membrane without ibuprofen. In a chicken model of flexor digitorum profundus tendon surgery, the ibuprofen-loaded PELA fibrous membranes prevented tissue adhesion and significantly reduced inflammation. Taken together, these results demonstrate that ibuprofen-loaded PELA fibrous membranes prevent peritendinous adhesion formation better than membranes that do not contain ibuprofen, through anti-adhesion and anti-inflammatory actions.
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