期刊
TISSUE ANTIGENS
卷 79, 期 4, 页码 287-290出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1399-0039.2011.01832.x
关键词
CD94; hematopoietic stem cell transplantation; HLA-E; HSCT; natural killer cell; NKG2A
资金
- German Red Cross Blood Transfusion Service, Baden-Wuerttemberg - Hessen
Human leukocyte antigen (HLA)-E is an inhibitory ligand of natural killer cells and ?/d T-cells. Differential expression of HLA-E alleles on the cell surface has been reported to influence outcome of hematopoietic stem cell transplantation (HSCT). We performed HLA-E genotyping in 116 HSCT patients and their HLA-matched unrelated donors. The impact of HLA-E genotypes on patient's overall survival (OS), disease free survival (DFS), cumulative incidences for relapse, transplant-related mortality (TRM) and acute graft vs host disease (aGvHD) was assessed. Neither univariate nor multivariate analysis showed any influence of HLA-E polymorphisms on the investigated endpoints of HSCT in our cohort. We could not confirm any of the previous observations in our cohort and consider it unlikely that HLA-E polymorphisms affect outcome of HSCT.
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