期刊
TISSUE ANTIGENS
卷 76, 期 6, 页码 431-439出版社
WILEY
DOI: 10.1111/j.1399-0039.2010.01587.x
关键词
acetylation; epigenetics; immune system; methylation
资金
- Formacion de Profesorado Universitario Spanish Research Programme
- Asturcor Foundation
- Spanish Ministry of Health [PI061267, PS09/02454]
- Spanish National Research Council (Consejo Superior de Investigaciones Cientificas) [200820I172]
- Obra Social Cajastur, Spain
Epigenetics comprises various mechanisms that mold chromatin structures and regulate gene expression with stability, thus defining cell identity and function and adapting cells to environmental changes. Alteration of these mechanisms contributes to the inception of various pathological conditions. Given the complexity of the immune system, one would predict that a higher-order, supragenetic regulation is indispensable for generation of its constituents and control of its functions. Here, we summarize various aspects of immune system physiology and pathology in which epigenetic pathways have been implicated. Increasing knowledge in this field, together with the development of specific tools with which to manipulate epigenetic pathways, might form a basis for new strategies of immune function modulation, both to optimize immune therapies for infections or cancer and to control immune alterations in aging or autoimmunity.
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