期刊
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
卷 120, 期 2, 页码 161-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2015.01.024
关键词
-
资金
- American Academy of Oral Medicine
- European Association of Oral Medicine
- New York University College of Dentistry
- Biocosmetics
- Elsevier
- Johnson and Johnson
- Oral Cancer Foundation
- Unilever
Objective. To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP). Study Design. We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included. Results. In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin. Conclusions. This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据