期刊
THROMBOSIS RESEARCH
卷 132, 期 1, 页码 63-68出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2013.04.001
关键词
Immune thrombocytopenia; Tolerogenic dendritic cells; Platelet; IL-10; TGF beta 1
资金
- National Natural Science Foundation of China [30801258]
- Star of Jinan Youth Science and Technology Project [20100114]
- China Post-doctoral Science Foundation [2012 M511036]
Activated platelet-specific autoreactive T cells play a key role in the pathophysiology of immune thrombocytopenia (ITP). Tolerogenic dendritic cells (tDCs) that induce T cells tolerance to platelet autoantigens are a promising strategy for specific cellular therapy in autoimmunity. In this study, we generated three kinds of GPIIb -specific tDCs stimulated by IL-10 (10-DCs), TGF beta 1 (T-DCs), or a combination of IL-10 and TGF beta 1 (10 T-DCs), respectively, and compared their phenotypes and biological function. Our data demonstrate that GPIIb-specific 10 T-DCs induced the weakest memory lymphocytes responses and exhibited stronger tolerogenic potential than others, making them suitable for tolerance inducing therapies. Furthermore, in ITP mice model we found that 10 T-DCs abrogated the decrease in platelet counts and the increase in serum IFN-gamma level, confirming the in vivo tolerogenic potential of 10 T-DCs. Our study provides a promising strategy for ITP intervention in the clinic by the induction of platelet-specific immune tolerance. (C) 2013 Elsevier Ltd. All rights reserved.
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