期刊
THROMBOSIS AND HAEMOSTASIS
卷 106, 期 2, 页码 371-378出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH10-12-0789
关键词
Malignancy; hypercoagulability; imaging
资金
- National Cancer Institute [K23 CA120587]
- National Heart, Lung and Blood Institute [1R01HL095109]
- V Foundation
Pancreatic cancer is known to be associated with VIE, but contemporary rates of incidental and symptomatic VIE events and their association with mortality are incompletely understood. We conducted a retrospective cohort study of consecutive pancreatic adenocarcinoma patients at the University of Rochester from 2006-2009. Data were analysed using a Cox model with time-dependent covariates. A total of 1,151 radiologic exams of 135 patients were included. Forty-seven patients (34.8%) experienced VIE including 12 pulmonary emboli (PE), 28 deep-vein thromboses (DVTs) and 47 visceral vein events. Incidental events comprised 33.3% of PEs, 21.4% of DVTs and 100% of visceral VTE. Median (95% CI) conditional survival beyond three months was 233 (162-322) more days for those without VIE, which was significantly greater than 12(3-60) days for those with DVT as first event (p<0.0001) and 87 (14-322) days with visceral first events (p = 0.022). In multivariate analysis, DVT (HR 25, 95% CI 10-63, p<0.0001), PE (HR 8.9, 95% CI 2.5-31.7, p = 0.007) and incidental visceral events (HR 2.6, 95% CI 1.6-4.2, p = 0.0001) were all associated with mortality, though anticoagulants reduced these risks by 70% (26-88%, p = 0.009). In conclusion, VIE occurs in over one-third of contemporary pancreatic cancer patients and, whether symptomatic or incidental, is strongly associated with worsened mortality. The role of anticoagulation in treating incidental or visceral VIE warrants further study.
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