期刊
THROMBOSIS AND HAEMOSTASIS
卷 105, 期 1, 页码 40-44出版社
SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
DOI: 10.1160/TH10-05-0293
关键词
DIC; Japanese Ministry Health and Welfare; ISTH; haemostatic markers; mortality; resolution rate
资金
- Ministry of Health, Labour and Welfare, Japan for Blood Coagulation Abnormalities
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japanese Society of Thrombosis and Haemostasis, Japanese DIG Study Group
There are three different diagnostic score systems for disseminated intravascular coagulation (DIC) established by the Japanese Ministry Health and Welfare (JMHW), the International Society on Thrombosis and Haemostasis (ISTH) and the Japanese Association for Acute Medicine (JAAM). The JMHW criteria are still used in Japan. In the present study, all three diagnostic criteria were used to prospectively evaluate 413 patients with different underlying diseases of DIC who were; treated at the Mie University Hospital (JMHW, n=166; ISTH, n=143; JAAM, n=291). The odds ratio (95% confidence interval) for death was 1.88 (1.22 - 2.90) in JMHW, 2.55 (1.65 - 3.95) in ISHT and 1.99 (1.19 - 3.32)in JAAM. The platelet count, prothrombin time, fibrin and fibrinogen degradation products and fibrinogen were significantly important for diagnosis of DIC by all three diagnostic criteria. Haemostatic molecular markers were significantly high in all patients and were useful for the diagnosis of DIC. The JAAM diagnostic criteria displayed a high sensitivity for DIC and the ISTH overt-DIC diagnostic criteria displayed a high specificity for DIC. All three diagnostic criteria for DIC were related to a poor patient outcome.
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