期刊
THROMBOSIS AND HAEMOSTASIS
卷 102, 期 6, 页码 1117-1134出版社
GEORG THIEME VERLAG KG
DOI: 10.1160/TH09-07-0472
关键词
Endothelial cells; angiogenesis; apoptosis; NF-kappaB; interferon
资金
- Deutsche Forschungsgemeinschaft [DFG-SPP 1130, DFG-SFB 566, DFG-GK 1071, DFG 317/2-1]
- Interdisciplinary Center for Clinical Research (IZKF) of the University of Erlangen-Nuremberg
- European Union [INCALSHC-CT-2005-018704]
Kaposi's sarcoma-associated herpesvirus (KSHV) / human herpesvirus-8 is the causative agent of the endothelial cell-derived tumour Kaposi's sarcoma. Herpesviruses possess large complex genomes which provide many options to regulate cellular physiology during the viral life cycle and in the course of tumourigenicity. Novel techniques of systems biology and reverse genetics are increasingly applied to dissect the complex interaction of KSHV with endothelial cells. This review will outline novel results and pitfalls of these technologies in the elucidation of KSHV pathogenicity.
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