期刊
THORAX
卷 69, 期 6, 页码 548-557出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2013-204198
关键词
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资金
- European Respiratory Society Fellowship [677]
- European Research Council Starting Investigator award
- Rosetrees Trust
- Roy Castle Lung Cancer Foundation
- UCLH Charitable foundation
- Department of Health's NIHR Biomedical Research Centre's funding scheme
- UCL ECMC
- Cancer Research UK [14895] Funding Source: researchfish
- Medical Research Council [G0500392] Funding Source: researchfish
- MRC [G0500392] Funding Source: UKRI
Background Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing severity of dysplasia to carcinoma in situ (CIS), and in some cases, ending in transformation to invasive carcinoma. Synchronous preinvasive lesions identified at autopsy have been previously shown to be clonally related. Methods Using autofluorescence bronchoscopy that allows visual observation of preinvasive lesions within the upper airways, together with molecular profiling of biopsies using gene sequencing and loss-of-heterozygosity analysis from both preinvasive lesions and from intervening normal tissue, we have monitored individual lesions longitudinally and documented their visual, histological and molecular relationship. Results We demonstrate that rather than forming a contiguous field of abnormal tissue, clonal CIS lesions can develop at multiple anatomically discrete sites over time. Further, we demonstrate that patients with CIS in the trachea have invariably had previous lesions that have migrated proximally, and in one case, into the other lung over a period of 12 years. Conclusions Molecular information from these unique biopsies provides for the first time evidence that field cancerisation of the upper airways can occur through cell migration rather than via local contiguous cellular expansion as previously thought. Our findings urge a clinical strategy of ablating high-grade premalignant airway lesions with subsequent attentive surveillance for recurrence in the bronchial tree.
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