期刊
THORAX
卷 67, 期 8, 页码 669-674出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2011-201321
关键词
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资金
- Talecris Biotherapeutics Inc.
- Fondazione IRCCS Policlinico San Matteo-Ricerca Corrente [RC345]
- Fondazione Cariplo
- The Swiss National Science Foundation [33CS30_134276/1, 33CSCO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, 3233-054996, PDFMP3-123171]
- Federal Office for Forest, Environment and Landscape
- Federal Office of Public Health
- Federal Office of Roads and Transport
- canton's government of Aargau
- canton's government of Basel-Stadt
- canton's government of Basel-Land
- canton's government of Geneva
- canton's government of Luzern
- canton's government of Ticino
- canton's government of Zurich
- Swiss Lung League
- canton's Lung League of Basel Stadt/Basel Landschaft
- canton's Lung League of Geneva
- canton's Lung League of Ticino
- canton's Lung League of Zurich
- SUVA
- Freiwillige Akademische Gesellschaft
- UBS Wealth Foundation
- Talecris Biotherapeutics GmbH
- Abbott Diagnostics
- European Commission [018996]
- Wellcome Trust [WT 084703MA]
- Kedrion SpA
- Grifols International SA
- Talecris GmbH
- Swiss National Science Foundation (SNF) [33CS30_134276] Funding Source: Swiss National Science Foundation (SNF)
Rationale alpha 1-Antitrypsin (AAT) deficiency is one of the commonest rare respiratory disorders worldwide. Diagnosis, assessment of risk for developing chronic obstructive pulmonary disease (COPD), and management of replacement therapy require the availability of precise and updated ranges for protein serum levels. Objective This paper aims to provide ranges of serum AAT according to the main genotype classes in the general population. Methods The authors correlated mean AAT serum levels with the main SERPINA1 variants (M1Ala/M1Val (rs6647), M3 (rs1303), M2/M4 (rs709932), S (rs17580) and Z (rs28929474)) in 6057 individuals enrolled in the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) cohort. Results The following ranges (5th-95th percentile) of AAT were found in the serum (g/litre): 1.050-1.640 for PI* MM, 0.880-1.369 for PI* MS, 0.730-1.060 for PI* SS, 0.660-0.997 for PI* MZ and 0.490-0.660 for PI* SZ. There was very little overlap in AAT serum levels between genotype classes generally not believed to confer an enhanced health risk (MM and MS) and those associated with an intermediate AAT deficiency and a potentially mildly enhanced health risk (SS, MZ). Conclusion This work resulted in three important findings: technically updated and narrower serum ranges for AAT according to PI genotype; a suggestion for a population-based `protective threshold' of AAT serum level, used in decision-making for replacement therapy; and more precise ranges framing the intermediate AAT deficiency area, a potential target for future primary prevention.
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