期刊
THORAX
卷 67, 期 1, 页码 54-61出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2011-200329
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资金
- UK Medical Research Council [G0401540]
- Wellcome Trust
- University of Bristol
- Nutricia Research Foundation
- MRC [G0401540] Funding Source: UKRI
- Medical Research Council [G0401540, G9815508] Funding Source: researchfish
Background Rates of preterm birth have increased in most industrialised countries but data on later lung function of late preterm births are limited. A study was undertaken to compare lung function at 8-9 and 14-17 years in children born late preterm (33-34 and 35-36 weeks gestation) with children of similar age born at term (>= 37 weeks gestation). Children born at 25-32 weeks gestation were also compared with children born at term. Methods All births from the Avon Longitudinal Study of Parents and Children (n = 14 049) who had lung spirometry at 8-9 years of age (n = 6705) and/or 14-17 years of age (n = 4508) were divided into four gestation groups. Results At 8-9 years of age, all spirometry measures were lower in the 33-34-week gestation group than in controls born at term but were similar to the spirometry decrements observed in the 25-32-week gestation group. The 35-36-week gestation group and term group had similar values. In the late preterm group, at 14-17 years of age forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were not significantly different from the term group but FEV1/FVC and forced expiratory flow at 25-75% FVC (FEF25-75%) remained significantly lower than term controls. Children requiring mechanical ventilation in infancy at 25-32 and 33-34 weeks gestation had in general lower airway function (FEV1 and FEF25-75) at both ages than those not ventilated in infancy. Conclusions Children born at 33-34 weeks gestation have significantly lower lung function values at 8-9 years of age, similar to decrements observed in the 25-32-week group, although some improvements were noted by 14-17 years of age.
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