期刊
THORAX
卷 66, 期 5, 页码 396-401出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thx.2010.146613
关键词
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资金
- European Commission
- Fondo de Investigaciones Santarias (FIS), Albacete [97/0035-01, 99/0034-01, 99/0034-02]
- Hospital Universitario de Albacete, Albacete
- Consejeria de Sanidad, Albacete
- FWO (Fund for Scientific Research)-Flanders Belgium, Antwerp [G.0402.00]
- University of Antwerp, Antwerp
- Flemish Health Ministry, Antwerp
- SEPAR, Public Health Service, Barcelona [R01 HL62633-01]
- Fondo de Investigaciones Santarias (FIS), Barcelona [97/0035-01, 99/0034-01, 99/0034-02]
- CIRIT, Barcelona [1999SGR 00241]
- 'Instituto de Salud Carlos III' Red de Centros RCESP, Barcelona [C03/09, C03/011]
- Swiss National Science Foundation, Basel
- Swiss Federal Office for Education Science, Basel
- Swiss National Accident Insurance Fund (SUVA), Basel
- Norwegian Research Council, Norwegian Asthma & Allergy Association (NAAF), Bergen
- Glaxo Wellcome AS, Bergen
- Norway Research Fund, Bergen
- Institut Pneumologique d'Aquitaine, Bordeaux
- GSF-National Research Centre for Environment Health, Erfurt
- Deutsche Forschungsgemeinschaft (DFG), Erfurt [FR 1526/1-1]
- Basque Health Department, Galdakao
- Swedish Heart Lung Foundation, Goteborg
- Swedish Foundation for Health Care Sciences & Allergy Research, Goteborg
- Swedish Asthma & Allergy Foundation, Goteborg
- Swedish Cancer & Allergy Foundation, Goteborg
- Programme Hospitalier de Recherche Clinique-DRC de Grenoble, Grenoble [2610]
- Ministry of Health, Direction de la Recherche Clinique, Grenoble
- Ministere de l'Emploi et de la Solidarite, Direction Generale de la Sante, Grenoble
- CHU de Grenoble, Grenoble
- Comite des Maladies Respiratoires de l'Isere, Grenoble
- GSF-National Reasearch Centre for Environment & Health, Hamburg
- Deutsche Forschungsgemeinschaft (DFG), Hamburg [MA 711/4-1]
- Asthma UK (formerly known as National Asthma Campaign) (UK), Ipswich and Norwich
- Fondo de Investigaciones Santarias (FIS), Huelva [97/0035-01, 99/0034-01, 99/0034-02]
- Programme Hospitalier de Recherche Clinique-DRC de Grenoble, Montpellier [2610]
- Ministry of Health, Direction de la Recherche Clinique, Montpellier
- CHU de Grenoble, Montpellier
- Ministere de l'Emploi et de la Solidarite, Montpellier
- Direction Generale de la Sante, Montpellier
- Aventis (France), Montpellier
- Direction Regionale des Affaires Sanitaires et Sociales Languedoc-Roussillon, Montpellier
- Fondo de Investigaciones Santarias (FIS), Oviedo [97/0035-01, 99/0034-01, 99/0034-02]
- Ministere de l'Emploi et de la Solidarite, Paris
- Direction Generale de la Sante, Paris
- UCB-Pharma (France), Paris
- Aventis (France), Paris
- Glaxo France, Paris
- Programme Hospitalier de Recherche Clinique-DRC de Grenoble, Paris [2610]
- Ministry of Health, Paris
- Direction de la Recherche Clinique, Paris
- CHU de Grenoble, Paris
- Glaxo-SmithKline Italy, Pavia
- Italian Ministry of University and Scientific and Technological Research (MURST), Paris
- Local University (Pavia, Italy)
- American Lung Association of Oregon, Portland
- Northwest Health Foundation, Portland
- Collins Foundation, Portland
- Merck Pharmaceutical, Portland
- Icelandic Research Council, Reykjavik
- Icelandic University, Reykjavik
- Estonian Science Foundation, Tartu
- ASL 4 Regione Piemonte (Italy), Turin
- AO CTO/ICORMA Regione Piemonte (Italy), Turin
- Ministero dell'Universita e della Ricerca Scientifica (Italy), Turin
- Glaxo Wellcome spa (Verona, Italy), Turin
- Swedish Heart Lung Foundation, Umea
- Swedish Foundation for Health Care Sciences & Allergy Research, Umea
- Swedish Asthma & Allergy Foundation, Umea
- Swedish Cancer & Allergy Foundation, Umea
- Swedish Heart Lung Foundation, Uppsala
- Swedish Foundation for Health Care Sciences & Allergy Research, Uppsala
- Swedish Asthma & Allergy Foundation, Uppsala
- Swedish Cancer & Allergy Foundation, Uppsala
- Medical Research Council [G0801056B] Funding Source: researchfish
Background There are few longitudinal studies that have examined the association of lung function decline with indoor mould and dampness. Lung function decline in relation to dampness and mould in the home has studied in adults over a 9 year period. Methods Spirometry was performed twice in participants in the European Respiratory Health Survey (ECRHS I and II) who were initially examined aged 20-45 years, in 1990-1995 and 9 years later (n=6443). Information on their current home was collected twice by interview. Dampness (water damage or damp spots) and indoor mould, ever and in the last 12 months, were assessed. A dampness score and a mould score were calculated. In addition, 3118 homes at 22 centres were inspected directly at follow-up for the presence of dampness and mould. Results Dampness and mould were common. Overall, 50.1% reported any dampness and 41.3% any indoor mould in either ECRHS I or ECRHS II. Women with dampness at home had an additional decline in forced expiratory volume in 1 s (FEV1) of -2.25 ml/year (95% CI -4.25 to -0.25), with a significant trend in increased lung function decline in relation to the dampness score (p=0.03). The association in women was significant when excluding those with asthma at baseline. Observed damp spots in the bedroom was associated with a significant additional decline in FEV1 of -7.43 ml/year (95% CI -13.11 to 1.74) in women. Conclusion Dampness and indoor mould growth is common in dwellings, and the presence of damp is a risk factor for lung function decline, especially in women.
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