期刊
OPEN BIOLOGY
卷 5, 期 12, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.150138
关键词
miR-302/367 cluster; evolution; transcriptional regulation; cell cycle; cellular signalling; epigenetic regulation
资金
- earmarked fund for China Agriculture Research System [CARS-40-10]
- [201303059]
microRNAs are a subclass of small non-coding RNAs that fine-tune the regulation of gene expression at the post-transcriptional level. The miR-302/367 cluster, generally consisting of five members, miR-367, miR-302d, miR-302a, miR-302c and miR-302b, is ubiquitously distributed in vertebrates and occupies an intragenic cluster located in the gene La-related protein 7 (LARP7). The cluster was demonstrated to play an important role in diverse biological processes, such as the pluripotency of human embryonic stem cells (hESCs), self-renewal and reprogramming. This paper provides an overviewof the mir-302/367 cluster, discusses our current understanding of the cluster's evolutionary history and transcriptional regulation and reviews the literature surrounding the cluster's roles in cell cycle regulation, epigenetic regulation and different cellular signalling pathways.
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