期刊
THORACIC AND CARDIOVASCULAR SURGEON
卷 57, 期 1, 页码 1-6出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1039060
关键词
cardiovascular surgery; coronary bypass surgery; heart disease
资金
- Ministry of Education, Czech Republic [MSM0021620812]
- Internal Grant Agency of Ministry of Health, Czech Republic [NR/9090-4]
Polymorphonuclear leukocytes or neutrophils are the main executors of cellular death, both in septic inflammation during bacterial infection and in sterile inflammation during trauma or surgery. Whereas in septic inflammation neutrophils perform a useful function to fortify the host's defense against infection, in sterile inflammation, by contrast, they contribute to Unwelcome tissue damage. Regardless of the Situation, activated neutrophils exhibit a prolonged life-span and delayed apoptotic death which, under normal conditions, is a prerequisite for their natural renewal. Traditionally, delayed neutrophil apoptosis was considered to promote trauma or surgical injury. According to the results of recent Studies, however Surprising they may appear, the reverse might be in keeping with what happens in vivo. Apoptotic signaling in neutrophils could, by contrast, contribute to intrinsic protection of the host's tissues. This review article, aimed preferentially but not exclusively at the cardiac Surgeon, presents some new information in support of this viewpoint, which fits in with our own observations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据